文章摘要
沈秋燕,干正琦,邵一川.血清胆红素与糖尿病视网膜病变相关性的临床研究[J].,2017,39(15):1294-1296.
血清胆红素与糖尿病视网膜病变相关性的临床研究
Relationship between serum bilirubin level and diabetic retinopathy
  
DOI:10.12056/j.issn.1006-2785.2017.39.15.2016-1937
中文关键词: 2 型糖尿病 糖尿病视网膜病变 胆红素
英文关键词: Type 2 diabetes mellitus Diabetic retinopathy Bilirubin
基金项目:
作者单位
沈秋燕 嘉兴市第一医院内分泌科 
干正琦  
邵一川  
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中文摘要:
      目的研究2型糖尿病患者血清胆红素与糖尿病视网膜病变之间的关系。方法将263例2型糖尿病患者是否合并糖尿病视网膜病变分为合并糖尿病视网膜病变组(DR组)78例和未合并糖尿病视网膜病变组(NDR组)185例,并对两组患者的临床特征进行分析比较,并对糖尿病视网膜病变的危险因素进行多因素logistic回归分析。结果与NDR组相比,DR组患者的糖尿病病程更长(P<0.01),胰岛素抵抗更明显(P<0.05),而TBil、DBil、间接胆红素水平均显著下降(P<0.05或0.01)。logistic回归分析显示:病程(OR=1.124)、年龄(OR=1.023)、BMI(OR=1.036)是其独立危险因素,TBil(OR=0.907)、DBil(OR=0.847)是其保护因素。结论DR的发生与血清胆红素水平下降有一定的相关性,血清胆红素可能是DR的一种有益标记物。
英文摘要:
      Objective To evaluate the relationship between serum bilirubin level and diabetic retinopathy. Methods Clinical data of 263 patients with type 2 diabetes mellitus(T2DM) admitted in Jiaxing First Municipal Hospital from Januray 2015 to February 2015 were retrospectively reviewed. The factors related to the diabetic retinopathy in T2DM patients were analyzed by Logistic regression. Results Among 263 patients there were 78 cases (29.7%) with diabetic retinopathy (DR). Compared with non-DR T2DM patients, the duration of DM in DR patients was significantly longer (P<0.01), the insulin resistance was more significant (P<0.05), while serum total bilirubin, direct bilirubin, indirect bilirubin levels was significantly lower (P<0.01, P<0.05, P <0.01).Logistic regression analysis showed that the duration of DM (OR=1.124), age (OR=1.023), BMI (OR=1.036) were independent risk factors of diabetic retinopathy, and total bilirubin (OR=0.907), direct bilirubin (OR=0.847) were protective factors. Conclusion Serum bilirubin levels in T2DM patients with DR are decreased, which indicates that bilirubin may be an useful biomarkers for increased risk of diabetic retinopathy in T2DM patients.
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